Protan

Protan is a proteinaceous domain derived from the C-terminal part of the lactococcal cell-wall hydrolase AcmA that binds to peptidoglycan (PGN). Mucosis scientists have generated a versatile plug and play toolbox of expression vectors that allow easy insertion of any proteinaceous antigen to produce antigen-Protan fusions in a wide variety of expression organisms, including eukaryotic cells. The use of a secretion peptide (SP) preceding the Ag-Protan fusion allows for the harvesting of the fusion protein from the growth medium (B). Purified Ag-Protan fusions bind instantly to BLPs upon mixing. The binding is non-covalent but highly stable. The resulting antigen-covered BLPs constitute the final Mimopath® vaccine that is delivered to humans via the mucosal layers of the nose (spray) or mouth (capsule), without the need for an injection (C).

mimopath base vaccine

Andre G, Leenhouts K, Hols P, Dufrêne YF. Detection and localization of single LysM-peptidoglycan interactions. J. Bacteriol. 2008; 190:7079–7086.

Zeng G, Chen J, Zhong L, Wang R, Jiang L, Cai J, Yan L, Huang D, Chen CY, Chen ZW. NSOM- and AFM-based nanotechnology elucidates nano-structural and atomic-force features of a Y. pestis V immunogen-containing particle vaccine capable of eliciting robust response. Proteomics 2009; 9:1538-1547.

07.11.16 Mucosis Initiates First-in-Human Study of SynGEM®, a Needle-Free Nasal Spray RSV Vaccine
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24.03.16 Mucosis to Present at World Vaccines Congress 2016
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20.01.16 Mucosis Secures €3.7M from Wellcome Trust to Fund Clinical Trials of its Respiratory Syncytial Virus Vaccine in Partnership with Imperial College London
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19.05.15 Mucosis to Present Data on Intranasal RSV Vaccine SynGEM® at Modern Vaccines Adjuvants & Delivery Systems 2015
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23.03.15 Mucosis to Present on Intranasal Respiratory Syncytial Virus Vaccine Candidate SynGEM® at BioCapital Europe
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10.11.14 Mucosis Presents Data on Intranasal Respiratory Syncytial Virus Vaccine SynGEM® at RSV2014 Symposium
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20.10.14 Mucosis Presents Data on Intranasal RSV Vaccine SynGEM® at Vaccines 2014 Conference
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