Shigella and other enteric bacterial pathogens vaccine
Diarrhea is the second-leading cause of death among children under the age of five worldwide, killing an estimated 1.5 million and hospitalizing millions more, mostly in developing countries. In addition, travelers and military personnel visiting the developing world are at high risk of suffering from diarrhea. The leading causes of diarrhea are bacterial and viral pathogens. The major leading bacterial causes of diarrhea are Shigella species, enterotoxigenic Escherichia coli (ETEC), Salmonella species, Campylobacter species and Yersinia species. There are currently no vaccines available that prevent diarrhea caused by these enteric bacterial pathogens. The development of vaccines against these bacteria is also stimulated by PATH, an international organization that supports the development of vaccines for children in low developing countries.
We have set out to develop an oral Mimopath®-based vaccine to prevent diarrhea caused by enteric bacteria. Our first oral prototype vaccine with Shigella antigens loaded onto BLPs has shown encouraging results. The final composition of the vaccine will include conserved protein antigens of several enteric bacteria that cause life-threatening diarrhea.