Shigella and other enteric bacterial pathogens vaccine

Diarrhea is the second-leading cause of death among children under the age of five worldwide, killing an estimated 1.5 million and hospitalizing millions more, mostly in developing countries. In addition, travelers and military personnel visiting the developing world are at high risk of suffering from diarrhea. The leading causes of diarrhea are bacterial and viral pathogens. The major leading bacterial causes of diarrhea are Shigella species, enterotoxigenic Escherichia coli (ETEC), Salmonella species, Campylobacter species and Yersinia species. There are currently no vaccines available that prevent diarrhea caused by these enteric bacterial pathogens. The development of vaccines against these bacteria is also stimulated by PATH, an international organization that supports the development of vaccines for children in low developing countries.

pneugemWe have set out to develop an oral Mimopath®-based vaccine to prevent diarrhea caused by enteric bacteria. Our first oral prototype vaccine with Shigella antigens loaded onto BLPs has shown encouraging results. The final composition of the vaccine will include conserved protein antigens of several enteric bacteria that cause life-threatening diarrhea.

 

07.11.16 Mucosis Initiates First-in-Human Study of SynGEM®, a Needle-Free Nasal Spray RSV Vaccine
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24.03.16 Mucosis to Present at World Vaccines Congress 2016
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20.01.16 Mucosis Secures €3.7M from Wellcome Trust to Fund Clinical Trials of its Respiratory Syncytial Virus Vaccine in Partnership with Imperial College London
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19.05.15 Mucosis to Present Data on Intranasal RSV Vaccine SynGEM® at Modern Vaccines Adjuvants & Delivery Systems 2015
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23.03.15 Mucosis to Present on Intranasal Respiratory Syncytial Virus Vaccine Candidate SynGEM® at BioCapital Europe
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10.11.14 Mucosis Presents Data on Intranasal Respiratory Syncytial Virus Vaccine SynGEM® at RSV2014 Symposium
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20.10.14 Mucosis Presents Data on Intranasal RSV Vaccine SynGEM® at Vaccines 2014 Conference
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